Brisbane has encountered a series of challenges and triumphs in the 21st century, particularly with major flooding events in January 2011 and February 2022. While the Brisbane River did not reach the catastrophic heights of the 1974 flood, both incidents caused considerable disruption and damage to the city’s infrastructure.

In response to these challenges, Brisbane has seen significant growth in its cultural and civic infrastructure. The Queensland Cultural Centre was notably expanded with the completion of the State Library and the Gallery of Modern Art in 2006, alongside the Kurilpa Bridge in 2009, which holds the title of the world's largest hybrid tensegrity bridge.

Brisbane has also established itself as a key player on the international stage, hosting high-profile events such as the final Goodwill Games in 2001, the Rugby League World Cup finals in 2008 and 2017, and the G20 Brisbane summit in 2014.

Population growth in Brisbane has remained robust, among the highest in Australian capital cities during the first two decades of the century. This growth is supported by a series of major infrastructure projects that include the Howard Smith Wharves, Roma Street Parklands, Queens Wharf, and the Brisbane Riverwalk. Additionally, developments like the Queen's Wharf casino and resort precinct, Brisbane International Cruise Terminal, Clem Jones, Airport Link, Legacy Way road tunnels, and new railway lines—covering the Airport, Springfield, Redcliffe Peninsula, and Cross River Rail—are either completed or underway.

Looking ahead, Brisbane is preparing to host the 2032 Summer Olympics and 2032 Summer Paralympics, a landmark event that promises to elevate the city’s profile globally and catalyze further development and investment in the region. The city’s ability to adapt and grow amidst adversity positions it as a vibrant hub of culture, sport, and community in Australia.